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. 2019 Jun 11;19:97. doi: 10.1186/s12871-019-0767-x

Table 3.

Haemostasis at the beginning and the end of liver transplantation as judged by conventional laboratory examinations and ROTEM™

Initial values Final values
Median Percentiles Median Percentiles Significance niveau
25% 75% 25% 75%
EXTEM
 CT (s) 55 46 78 62 51 83 p < 0.001
 CFT (s) 119 82 177.5 163 117.5 251 p < 0.001
 MCF (mm) 53 45 62 49 43 57 p < 0.001
 Alpha (°) 68 59 75 64 54 72 p < 0.001
INTEM
 CT (s) 188.5 162 217.8 254.5 205 326.8 p < 0.001
 CFT (s) 104 67 156 153.5 100 240.3 p < 0.001
 MCF (mm) 52 45 61 49 42 56 p < 0.001
 Alpha (°) 70 61 77 65 55 72 p < 0.001
FIBTEM
 CT (s) 54 45 75.5 61.5 50 83 p = 0.02
 CFT (s) * * * * * *
 MCF (mm) 15 11 23 11 8 15 p < 0.001
 alpha (°) 67 54.5 74 63 51 73 p < 0.001
APTEM
 CT (s) 64 51 88.5 71 55 93 p < 0.001
 CFT (s) 128 92 182 167 119.5 247.5 p < 0.001
 MCF (mm) 52 45.8 61 49 43 55 p < 0.001
 alpha (°) 67 59 73 63 54 71 p < 0.001
 INR 1.48 1.26 1.81 2.47 1.85 3.26 p < 0.001
 aPTT (s) 45 36.9 56 81 58.1 108.9 p < 0.001
 fibrinogen (mg/dl) 175.3 114.8 257 118 91 162 p < 0.001
 antithrombin (%) 45.6 32 68.4 24.5 12.5 37.9 p < 0.001
 platelets (1/103 μl) 92 62 148.5 98 71 139 n.s.
 Hb (g/dl) 10.1 8.9 11.5 9.9 9 11.1 p < 0.001

ROTEM™ values shown are clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF), and angle alpha (alpha). Whole blood samples were activated with tissue factor (EXTEM™), elagic acid (INTEM™), tissue factor and platelet inhibition (FIBTEM™), and tissue factor and fibrinolysis inhibition (APTEM™). Conventional laboratory variables are international normalized ratio (INR), activated partial thromboplastin time (aPTT), fibrinogen concentration, antithrombin activity, platelet count, and hemoglobin concentration (Hb). ROTEM™ guided haemostasis management resulted in a slight decrease in most haemostatic variables during the transplantation procedure. Note, that CFT values are not generated in the FIBTEM assay. Differences between initial and final values were determined using the paired Wilcoxon test.

*: no clot formation detectable