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. Author manuscript; available in PMC: 2019 Sep 1.
Published in final edited form as: Nature. 2019 Feb 27;567(7746):56–60. doi: 10.1038/s41586-019-0988-7

Fig. 2. Structure of the IFNγ hexameric complex.

Fig. 2

a, The structure of the IFNγ hexameric complex reveals the mechanism of IFNγR2 (green) recognition of IFNγ (blue and tan) and IFNγR1 (grey). IFNγR2 receptors make extensive contacts with the IFNγ dimer at sites 2a and 2b, and site 3a and 3b makes stem–stem contacts with IFNγR1. b, Structure of the IFNλ–IFNλR1–IL-10Rβ signalling complex (PDB: 5T5W)15 shares a similar geometry with the IFNγ signalling complex. The binding mode of IFNγR2 is nearly identical to that of IL-10Rβ. c, Structure of a type I IFN receptor complex (PDB: 3SE4)21 with distinct ligand–receptor geometries compared to either type II or III IFNs.