Table 2.
Interventions included in the literature review*
| Intervention | Name/type |
|---|---|
| NSAIDs |
Any |
| DMARDs | Leflunomide, methotrexate, sulfasalazine, triple non–biologic DMARD (methotrexate, sulfasalazine, hydroxychloroquine)† |
| Biologics TNFi |
Adalimumab, etanercept, infliximab, golimumab† |
| Non–TNFi | Abatacept (CTLA-4Ig), tocilizumab (anti– interleukin-6 receptor), rituximab (anti- CD20)‡ |
| Glucocorticoids | |
| Oral | Any Triamcinolone acetonide, triamcinolone |
| Intraarticular | hexacetonide, methylprednisolone acetate |
| Other interventions | Physical therapy Occupational therapy |
NSAIDs = nonsteroidal antiinflammatory drugs; DMARDs = disease-modifying antirheumatic drugs; TNFi = tumor necrosis factor inhibitor.
Certolizumab was not included in the recommendations because no pediatric data were yet available.
Evaluated for polyarthritis only.