Fig. 1.

Association of FUSION physiological traits with skeletal muscle gene expression and DNAme, controlling for estimated fiber type proportions. Analysis performed with base covariates (sex, age, sample collection site, smoking status, and molecular-trait specific technical covariates), plus tissue type (base+tissue, green bars and points), or base+tissue plus fiber type covariates (base+tissue+fiber, orange bars and points). (A) Percentage of DNAme sites or genes (x axis) associated with each physiological trait (y axis; FDR ≤ 1%). (B) Scatter plot of the number of DNAme sites (y axis) and number of genes (x-axis) associated with each physiological trait adjusting for base+tissue or for base+tissue+fiber covariates (results for a given trait connected with black line).