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Structural changes in the Ehmt2m-z+ and Setdb1m-z+ zygotes. Quantification of the area of the maternal and paternal pronucleus is depicted in Ehmt2m-z+ (A) and Setdb1m-z+ (B) zygotes compared with control zygotes. NLB counts in the maternal and paternal pronucleus of Ehmt2m-z+ (C) and Setdb1m-z+ (D) zygotes are also shown. The Ehmt2m-z+ and Setdb1m-z+ results are derived from the immunostaining experiments depicted in Fig. 1 and Fig. 3, respectively.
