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. 2019 May 13;116(22):10927–10936. doi: 10.1073/pnas.1821301116

Fig. 1.

Fig. 1.

CHD4 depletion results in a total decrease of bone marrow and spleen cellularity. (A) Total cell counts of bone marrow cells harvested from 4- to 6-wk-old Cd79afl/flCd79a-CreTg/+ (cKO; n = 21) mice and WT (n = 14) mice. Each dot represents an individual mouse. (B) Total cell counts of splenocytes harvested from 4- to 6-wk-old Chd4fl/flCd79a-CreTg/+ (n = 47) and WT (n = 61) mice. Each dot represents an individual mouse. (C) Flow cytometry and (D) total numbers of B220+CD19+ cells isolated from bone marrow of Chd4fl/flCd79a-CreTg/+ (n = 13) and WT (n = 10) mice. Each dot represents an individual mouse. Asterisks indicate statistical significance compared with WT littermate controls as unpaired, two-tailed Student’s t test without Welch’s correction. *P < 0.05, ****P < 0.0001. Graphs represent arithmetic mean with ±SEM. All data are representative of at least three independent experiments.