Fig. 4.

IL-17A/F regulates cytokine and host defense peptide expression in S. aureus-infected skin. S. aureus skin infection was performed on IL-17A/F^−/− and wt mice and infected skin tissue was harvested on day 7 (n = 5–10 per group). (A) Mean mRNA levels of cytokines (arbitrary units; AU) ± SEM. (B) Mean protein levels (pg/mg of tissue) ± SEM. (C) Mean levels of host defense peptides (AU) ± SEM. *P < 0.05, ^†P < 0.01, ^‡P < 0.001, as calculated by a two-tailed Student’s t test. n.d., not detected; n.s., not significant. Data are representative of two independent experiments.