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. 2019 May 14;116(22):10952–10961. doi: 10.1073/pnas.1814246116

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Copyright © 2019 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 1. — Effects of IKKβ knockout on behavior in male R6/1 mice. Pole test (8, 12, and 16 wk) and rotarod (8, 13, and 15 wk) are shown for tamoxifen (TAM)- vs. oil-treated R6/1 (HD) and NT controls (n = NT-Oil, 12; NT-TAM, 12; HD-Oil, 9; HD-TAM, 12 at week 8, and NT-Oil, 12; NT-TAM, 11; HD-Oil: 9, HD-TAM, 10 following injections). HD mice performed significantly worse on 12-wk pole test (A) and on weeks 13 and 15 rotarod (B) with TAM-induced IKKβ knockout than oil-treated HD control mice. No significant effect was observed in NT control mice with TAM-induced IKKβ knockout. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 values represent means ± SEM. Statistical significance was determined by one-way ANOVA with Bonferroni posttesting.