Fig. 4.

Correlation analysis of changes in activity patterns and in movement trajectories. CCs between the single-trial activity pattern on each day and the learned activity pattern plotted against the CCs between the single-trial movement trajectory on each day and the learned movement pattern are shown for all D1-Cre mice (A, n = 20) and D2-Cre mice (C, n = 20). Curves illustrating the percentage distribution of movement CCs [% (Move)] (Top) and percentage distribution of activity CCs [% (Activity)] (Right) at early (E1–E3) and late (L1–L3) stages. Thin and thick lines represent the mean (averaged over 0.2 bins) for individual mice and for all mice, respectively. Note that the increased percentages of higher activity CCs coincided with increased percentages of higher movement CCs at the late stage of learning (***P < 0.001, **P < 0.01 by Wilcoxon rank sum test). Averaged activity CCs with different movement CCs (at 0.2 CC bins) plotted against the movement CCs at the early (blue) and late (orange) stages of experiments are shown for D1-Cre (B) and D2-Cre (D) mice. Significant differences were found among data points at the late stage (P < 0.001 by one-way ANOVA; ***P < 0.001, **P < 0.01 by Wilcoxon rank sum test; numbers of mice used are shown in parentheses) and between the early and late stages at the same bin of movement CCs (P < 0.001 in bins 1–6 for D1-Cre mice, P < 0.05 and P < 0.001 in bins 1 and 2–6 for D2-Cre mice by Wilcoxon rank sum test). Error bars represent SEM.