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. 2019 Jun 5;9:184. doi: 10.3389/fcimb.2019.00184

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Copyright © 2019 Ufermann, Domröse, Babel, Tersteegen, Cengiz, Eller, Spekker-Bosker, Sorg, Förster and Däubener.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of mIDO1 in murine lung tissue during Toxoplasma gondii infection. Gene and protein expression in tissues from naïve or T. gondii ME49-infected wild-type (WT) and indoleamine 2,3-dioxygenase 1-deficient (IDO^−/−) mice. Western blot analysis shows murine IDO (mIDO) and β-actin protein in lung, liver, and brain tissue of naïve (–) and infected (+) WT and IDO^−/− mice (A). Expression of murine guanylate binding protein 2 (mGBP2), mIDO1, and mIDO2 in lung tissue homogenates of infected mice relative to their expression in naïve control samples (B). Data were normalized to the housekeeping gene β-actin and were represented as 2^−ΔΔCT (naïve vs. infected) in scattered dot plots and means ± standard deviation. The Student's t-test (unpaired, two-tailed) was used to determine statistical differences marked with asterisks (n.s., not significant; ***p ≤ 0.0001).