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. 2019 Jun 5;9:184. doi: 10.3389/fcimb.2019.00184

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Copyright © 2019 Ufermann, Domröse, Babel, Tersteegen, Cengiz, Eller, Spekker-Bosker, Sorg, Förster and Däubener.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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mIDO1 activity in murine lung tissue during Toxoplasma gondii infection. Serum and lung samples were collected from naïve or T. gondii ME49-infected wild-type (WT) and indoleamine 2,3-dioxygenase 1-deficient (IDO^−/−) mice. Free tryptophan and kynurenine was measured via high-performance liquid chromatography in serum (A) and lung tissue homogenate samples (B). Comparison of the T. gondii load (determined by B1-gene detection) in lungs of naïve or infected WT and IDO^−/− mice (C). Data are represented as scattered dot plots and means (±standard error of the mean for RT-PCR data). For the RT-PCR data, each dot represents the mean of duplicate measurements of a single mouse lung tissue sample. The Student's t-test (unpaired, two-tailed) was used to determine statistical differences marked with asterisks (n.s., not significant; *p ≤ 0.05, **p ≤ 0.001, and ***p ≤ 0.0001).