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. 2019 May 16;116(23):11380–11389. doi: 10.1073/pnas.1901407116

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Fig. 4. — Enhanced activation of IRF3 and IRF7 in Lrba^−/− cells stimulated with TLR3 or TLR9 ligands. (A) Immunoblot analysis of phosphorylated (p) or total IKKα/β, NF-κB p65, ERK1/2, and IκBα in Lrba^+/+, Lrba^+/−, and Lrba^−/− BMDCs after stimulation with CpG-B. (B and C) Immunoblot analysis of (B) IRF7, NF-κB p65, and (C) IRF3 in nuclear and cytoplasmic fractions of lysates of Lrba^+/+ and Lrba^−/− BMpDCs after stimulation with (B) CpG-A and (C) poly(I:C). (D) Immunoblot analysis of phosphorylated (p) and total IRF3 in Lrba^+/+, Lrba^+/−, and Lrba^−/− BMpDCs after stimulation with poly(I:C). Data are representative of three independent experiments.