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. 2019 May 16;116(23):11380–11389. doi: 10.1073/pnas.1901407116

Fig. 6.

Fig. 6.

Knockout of UNC93B1 partially rescues DSS-induced colitis in Lrba−/− mice. BM transplantation was performed using mice of the indicated genotypes (donor > recipient). (A) Body weight (% relative to weight on day 0), (B) DAI, and (C) hematoxylin and eosin staining of colon sections on day 10 after initiation of DSS treatment. (Scale bars, 25 μm.) (D) RT-qPCR analysis of the indicated mRNAs in colons from the indicated BM chimeric mice on day 10 after initiation of DSS treatment. Each symbol (A, B, and D) represents an individual mouse. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001 (one-way ANOVA with post hoc Tukey multiple comparisons test). Data are representative of four independent experiments (mean ± SD in A, B, and D).