Fig 1.

PRISMA individual patient data (IPD) flow diagram. A total of 9598 studies were scanned after removing duplicates. After full text review of 580 publications, 154 studies remained for which IPD were sought. IPD were retrieved for 76 studies including 7813 participants. For this analysis, 2481 participants of 11 studies had to be excluded, mainly because angina pectoris type was not classified or other data for pretest probability (PTP) calculation were missing (1610). Further reasons for exclusion of participants from the main analysis included coronary stents or bypass grafts, unstable angina pectoris, and non-diagnostic, invasive, coronary angiography examinations. A total of 5332 patients were included in this IPD analysis. ICA=invasive coronary angiography