TABLE 3.

Differentially regulated sRNA molecules during citramalate production

sRNA	Function	Fold change
		Preinduction samplesa				Production strain vs control strainb
		CS2	CS3	TS2	TS3	TS2:CS3	TS3:CS3
ChiX	Chitosugar catabolism	3.7	1.7	2.5	1.7	NSc	NS
CsrB	Antagonist of global translational regulator CsrA	3.0	1.3	NS	0.3	0.4	0.2
GadY	Acid tolerance—enhances stability of gadX transcript	NS	NS	1.3	2.1	2.0	3.0
MicF	Regulation of OmpF	2.3	1.6	NS	NS	NS	NS
RprA	Activation of RpoS-dependent acid tolerance	NS	NS	1.3	2.5	1.7	2.8
RybA	Regulation of TyrR	2.4	1.3	NS	NS	NS	NS
RyeA	Possible regulator of OmpD	3.0	1.7	NS	NS	NS	NS
RyfD	Overexpression inhibits biofilm formation	2.4	1.3	NS	NS	NS	NS
RygD	Unknown	2.6	1.4	NS	NS	NS	NS
RygE	Unknown	2.6	1.4	NS	NS	NS	NS
RyhB	Iron homeostasis	3.5	1.5	3.3	1.6	NS	NS
RyjA	Upregulated in intracellular Salmonella	3.1	2.0	2.2	2.1	NS	NS
SroC	Overexpression inhibits biofilm formation	0.4	0.5	NS	NS	NS	NS
SroG	Phantom gene?	2.7	1.4	NS	NS	NS	NS
Tff	Probable attenuator of rpsB expression	2.2	1.4	NS	NS	NS	NS

^aDifferences in the abundances of the indicated sRNA species relative to the preinduction samples (CS1 and TS1). Only those sRNA species that exhibited ≥2-fold change (FDR adjusted P value of ≤0.05) for one or more samples are shown.

^bDifferences in the abundances of the indicated sRNA species in the production strain (TS2 and TS3) relative to those in the control strain (CS2 and CS3). Only those sRNA species that exhibited ≥2-fold change (unadjusted P value of ≤0.05) for one or more comparisons are shown.

^cNS, not significant.