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. 2019 Jun 5;10:639. doi: 10.3389/fphar.2019.00639

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Copyright © 2019 Li, Zhang, Nie, Long, Qu and Yue

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of KR-12-a5 on LPS-induced bone erosion in vivo. (A) Scanned images from micro-CT. (B) The bone volume/tissue volume (BV/TV), Trabecular number (Tb.N), Trabecular separation (Tb.Sp), and connectivity density (Conn. D) from the micro-CT data (*P < 0.05, **P < 0.01, ***P < 0.001). (C) Representative images of decalcified bone stained with H&E, Masson, and TRAP. Bars represent 500 μm. (D) Quantitative analyses of Trabecular area percentage (Tb.Ar%), Tb.Sp, Collagen fiber area percentage (Col.Ar%), and number of TRAP-positive cells per unit area (NO. Trap+ Cell) (*P < 0.05, **P < 0.01).