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. 2019 Jun 15;27(12):2466–2479. doi: 10.1016/j.bmc.2019.02.048

Figure 4.

Figure 4

Screening of VHL-CRBN hetero-PROTACs. Western blot analysis of CRBN and VHL levels following 4 h treatment of HeLa cells with 1 µM compound. Values reported below each lane indicate protein abundance relative to the average 0.1% DMSO vehicle, and normalized for loading control.