Table 3.
ECCO2R compared to standard care for acute respiratory distress syndrome
| Patient or population: adults with ARDS Settings: intensive care Intervention: ECCO2R Comparison: standard care | ||||
| Outcomes | Relative effect (95% CI) | No. of participants (studies) | Quality of evidence (GRADE) | Comments |
| Mortality (hospital) | No MA conducted | 457 (13 studies) |
+--- VERY LOW Due to serious risk of bias, serious inconsistency, serious indirectness and serious imprecision |
Mostly observational studies. Only two RCTs performed. No MA performed as variable approach to ECCO2R and standard ventilator strategies. Mortality estimates presented as simple descriptions 27%–75% (mean 55.5%, SD 47.2 to 60.3) |
| Adverse events | No MA conducted | 485 (13 studies) |
+--- VERY LOW Due to serious risk of bias, serious inconsistency, serious indirectness and serious imprecision |
0%–25% incidence of arterial injury. Higher incidence of transfusion reported in two studies. Complications presented as aggregated simple descriptions—0%–25% |
ECCO2R, extracorporeal carbon dioxide removal.