Table 5.
HFOV compared to usual care for ARDS
| Patient or population: adults with ARDS Settings: intensive care Intervention: HFOV Comparison: standard care | ||||||
| Outcomes | Illustrative comparative risks (95% CI) | Relative effect (95% CI) | No. of participants (studies) | Quality of evidence (GRADE) | Comments | |
| Control risk | Intervention risk | |||||
| Standard care | HFOV | |||||
| Mortality (ICU) | 308 per 1000 | 442 per 1000 (308 to 447) |
RR 1.22 (0.93 to 1.60) |
1321 (three studies) |
+++- MODERATE Due to moderate inconsistency and mild indirectness |
Changes in conventional ventilation strategies accounted for heterogeneity |
| Mortality (30 day) | 436 per 1000 | 453 per 1000 (362 to 571) |
RR 1.04 (0.83 to 1.31) |
1580 (five studies) |
+++- MODERATE Due to moderate inconsistency and mild indirectness |
Changes in conventional ventilation strategies accounted for heterogeneity |
| Adverse events: barotrauma | 122 per 1000 | 147 per 1000 (101 to 212) |
RR 1.205 (0.834 to 1.742) |
752 (four studies) |
++-- LOW Due to serious imprecision |
Barotrauma variably defined |
| Adverse events: oxygen failure | 102 per 1000 | 77 per 1000 (61 to 89) |
RR 0.557 (0.351 to 0.884) |
757 (three studies) |
++-- LOW Due to serious imprecision |
Oxygenation failure variably defined. |
ARDS, acute respiratory distress syndrome; HFOV, high-frequency oscillatory ventilation.