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. 2019 May 4;6(1):e000431. doi: 10.1136/bmjresp-2019-000431

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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CONSORT diagram of the patients included in the systemic biomarker study completed only in the USA, as part of the SUMMIT international trial. CC-16, club cell protein 16; CONSORT, Consolidated Standards of Reporting Trials; CRP, C reactive protein; SPD, surfactant protein D; sRAGE, soluble receptor of activated glycogen end-product.