Table 3.

Univariable and multivariable associations in four evidence-based drug classes (ATC code)

	Antithrombotics (B01)		Lipid-lowering (C10)		Thyroid meds (H03)		Respiratory inhalers (R03)
	Unadjusted OR (95% CI, p value)	Adjusted OR (95% CI, p value)	Unadjusted OR (95% CI, p value)	Adjusted OR (95% CI, p value)	Unadjusted OR (95% CI, p value)	Adjusted OR (95% CI, p value)	Unadjusted OR (95% CI, p value)	Adjusted OR (95% CI, p value)
Hospitalised vs non-hospitalised	0.95 (0.82 to 1.10), p=0.49	0.95 (0.81 to 1.11), p=0.49	1.04 (0.89 to 1.20), p=0.64	0.92 (0.78 to 1.08), p=0.29	0.68 (0.46 to 1.00), p=0.05	0.62 (0.40 to 0.96), p=0.03	0.62 (0.49 to 0.78), p=0.001	0.63 (0.49 to 0.80), p<0.001
Age (years)	1.02 (1.01 to 1.03), p<0.001	1.03 (1.02 to 1.04), p<0.001	1.04 (1.03 to 1.05), p<0.001	1.05 (1.04 to 1.06), p<0.001	1.03 (1.01 to 1.05), p=0.002	1.06 (1.04 to 1.09), p<0.001	1.02 (1.01 to 1.03), p=0.004	1.04 (1.02 to 1.05), p<0.001
Gender Female vs male	1.02 (0.89 to 1.17), p=0.79	1.00 (0.87 to 1.15), p=0.99	0.85 (0.74 to 0.96), p=0.01	0.82 (0.72 to 0.95), p=0.01	0.84 (0.57 to 1.24), p=0.38	0.85 (0.56 to 1.30), p=0.46	1.04 (0.85 to 1.28), p=0.68	1.03 (0.83 to 1.27), p=0.79
Insurance type Private vs GMS/DVC patients	5.10 (4.31 to 6.04), p<0.001	5.35 (4.50 to 6.34), p<0.001	4.78 (4.06 to 5.62), p<0.001	5.68 (4.48 to 6.73), p<0.001	9.79 (6.90 to 13.89), p<0.001	11.67 (8.02 to 16.96), p<0.001	3.66 (2.78 to 4.82), p<0.001	3.75 (2.84 to 4.96), p<0.001
Number of repeat drug classes	0.99 (0.98 to 1.01), p=0.56	0.99 (0.97 to 1.01), p=0.28	1.01 (1.00 to 1.04), p=0.04	1.01 (0.99 to 1.04), p=0.24	0.98 (0.95 to 1.02), p=0.41	0.98 (0.94 to 1.03), p=0.44	0.97 (0.94 to 0.99), p=0.01	0.97 (0.94 to 0.99), p=0.02
Charlson score (≥1 vs 0)	0.93 (0.80 to 1.07), p=0.31	0.94 (0.80 to 1.09), p=0.41	1.05 (0.91 to 1.21), p=0.48	0.98 (0.84 to 1.14), p=0.78	0.78 (0.56 to 1.08), p=0.15	0.80 (0.54 to 1.15), p=0.22	0.66 (0.53 to 0.81), p<0.001	0.71 (0.58 to 0.88), p=0.002
No of consultations in enrolment period	1.00 (0.99 to 1.01), p=0.62	1.00 (0.99 to 1.01), p=0.63	1.00 (0.99 to 1.01), p=0.69	1.00 (0.99 to 1.01), p=0.75	0.99 (0.97 to 1.00), p=0.11	1.00 (0.98 to 1.02), p=0.83	0.99 (0.98 to 1.00), p=0.02	1.00 (0.99 to 1.01), p=0.72

Adjusted model includes gender, age, insurance type, Charlson Index, number of repeat drugs, number of consultations in the enrolment period.

ATC, Anatomical Therapeutic Chemical classification system; GMS, general medical services; DVC, doctor visit card.