. Author manuscript; available in PMC: 2019 Jun 12.

Published in final edited form as: J R Stat Soc Ser C Appl Stat. 2018 Jun 13;68(2):385–410. doi: 10.1111/rssc.12291

Table 5.

Time duration comparison between the ACD algorithm and the single cohort under AAA^†

Scenario	Algorithm	Mean (days)	Minimum ∼ maximum (days)	p-value
1	Cohort expansion	993.2 (161.9)	35 ∼ 1078	0:0687
1	Single cohort	1030.54 (102.4)	35 ∼ 1078	0:0687
2	Cohort expansion	986.01 (172.01)	35 ∼ 1074	0:0126^‡
2	Single cohort	1029.43 (110.76)	35 ∼ 1076	0:0126^‡
3	Cohort expansion	935.1 (201.36)	35 ∼ 1075	< 0:0001^§
3	Single cohort	1023.29 (108.68)	35 ∼ 1072	< 0:0001^§
4	Cohort expansion	741.75 (448.36)	34 ∼ 1077	0.6843
4	Single cohort	749.91 (448.76)	34 ∼ 1071	0.6843
5	Cohort expansion	984.25 (221.82)	13 ∼ 1075	0.4032
5	Single cohort	992.41 (214.45)	13 ∼ 1083	0.4032
6	Cohort expansion	979.98 (178.49)	28 ∼ 1073	0:0021^‡
6	Single cohort	1022.02 (129.18)	28 ∼ 1078	0:0021^‡
7	Cohort expansion	1001.89 (159.84)	35 ∼ 1079	0:0714
7	Single cohort	1044.55 (91.66)	35 ∼ 1083	0:0714
8	Cohort expansion	1027.4 (100.73)	36 ∼ 1075	0.4143
8	Single cohort	1035.1 (79.58)	35 ∼ 1078	0.4143
9	Cohort expansion	1024.49 (104.33)	35 ∼ 1076	0.3268
9	Single cohort	1036.92 (75.89)	35 ∼ 1078	0.3268
10	Cohort expansion	988.3 (168.62)	35 ∼ 1075	< 0:0113^‡
10	Single cohort	1028.7 (110.98)	35 ∼ 1078	< 0:0113^‡
11	Cohort expansion	997.2 (166.25)	24 ∼ 1072	0:2232
11	Single cohort	1023.39 (134.85)	24 ∼ 1084	0:2232

^†

Entries are the simulated trial duration in days for two-agent trials with a sample size of 96 patients.

^‡

p-value < 0.05.

^§

p-value < 0.0001.