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Perturbation of HER-1 signaling in trastuzumab and lapatinib resistant, HER-2 positive breast cancer cells via siRNA transient transfection and panitumumab treatment. A, Western analysis after siRNA transient transfection. Con: non-targeting control siRNA; KD: siRNA targeting HER-1. B, SiRNA mediated HER-1 knock down decreased cell proliferation. C, Panitumumab treatment decreased cell proliferation. (★ denotes P < 0.05).
