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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Crit Care Med. 2019 Mar;47(3):e241–e249. doi: 10.1097/CCM.0000000000003620

Figure 2. Myocardial Mitochondrial Respiration.

Figure 2.

Comparisons of measures of mitochondrial respiration in the right and left ventricular myocardium 24 hours after return of spontaneous circulation (treatment groups) or 24 hours post-anesthesia (sham). (a) Right and (d) left ventricle complex I respiration (OXPHOSCI) with complex I substrates malate, pyruvate, and glutamate. (b) Right and (e) left ventricle complex II respiration (ETCCII) with the addition of succinate and inhibition of complex I respiration with rotenone. (c) Right and (f) left ventricle maximal non-phosphorylating oxidative phosphorylation (ETCCI+CII) with the titration of the protonophore, FCCP, in the presence of complex I and complex II substrates. ANOVA with multiple comparisons of treatment groups to sham (*, p <0.05; **, p <0.01; ***, p <0.001). ANOVA with multiple comparisons between treatment groups (#, p <0.05; ##, p <0.01; ###, p <0.001). Definition of abbreviations: DG-CPR = depth-guided CPR; HD-CPR = hemodynamic-directed CPR.