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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Crit Care Med. 2019 Mar;47(3):e241–e249. doi: 10.1097/CCM.0000000000003620

Figure 3. Cerebral Mitochondrial Respiration.

Figure 3.

Comparisons of measures of mitochondrial respiration in the cerebral cortex (a-c) and hippocampus (d-f) 24 hours after return of spontaneous circulation (treatment groups) or 24 hours post-anesthesia (sham). (a) Cortical and (d) hippocampal complex I respiration (OXPHOSCI) with complex I substrates malate and pyruvate. (b) Cortical and (e) hippocampal complex II respiration (ETCCII) with the addition of succinate and inhibition of complex I respiration with rotenone. (c) Cortical and (f) hippocampal maximal oxidative phosphorylation convergence respiration (OXPHOSCI+CII) with both complex I and complex II substrates. Statistical analyses performed with ANOVA with multiple comparisons of treatment groups to sham (*, p <0.05; **, p <0.01; ***, p <0.001) and ANOVA with multiple comparisons between treatment groups (#, p <0.05; ##, p <0.01; ###, p <0.001). Definition of abbreviations: DG-CPR = depth-guided CPR; HD-CPR = hemodynamic-directed CPR.