Table 1.
Physiologic Measurements | DG-CPR | HD-CPR | p |
---|---|---|---|
Aortic Systolic Pressure (mmHg) | 60.5 (7.1) | 85.5 (10.5) | 0.02 |
Aortic Diastolic Pressure (mmHg) | 16.8 (2.7) | 31.3 (4.0) | <0.001 |
Right Atrial Diastolic Pressure (mmHg) | 9.5 (0.6) | 10.8 (0.9) | 0.16 |
Coronary Perfusion Pressure (mmHg) | 9.6 (2.1) | 21.0 | <0.001 |
End-tidal Carbon Dioxide (mmHg) | 39.7 (3.1) | 35.9 (4.5) | 0.39 |
Brain Tissue Oxygenation (% baseline) | 59.2 (16.1) | 233.8 (27.9) | <0.001 |
Chest Compression Rate (min−1) | 100.1 (0.1) | 100.0 (0.1) | 0.40 |
Chest Compression Depth (cm) | 4.4 (0.2) | 3.4 (0.3) | 0.02 |
Chest Compression Release Velocity (mm/sec) | 276.8 (7.3) | 257.4 (9.7) | 0.12 |
Comparisons between treatment groups from minutes 2-10 of resuscitation period, compared using generalized estimating equation (GEE) regression model accounting for clustering of data points within individual animals. Values are means from entire 8-minute period, with standard errors of the mean in parentheses. Definition of abbreviations: DG-CPR = depth-guided cardiopulmonary resuscitation; HD-CPR = hemodynamic-guided cardiopulmonary resuscitation.