Table 1. Top 50 genes specifically upregulated by CDM-3008 treatment.
| Average | ||||||
|---|---|---|---|---|---|---|
| Rank | Gene ID | Symbol | Entrez Gene Name | Type(s) | IFN /DMSO | CDM /DMSO |
| 1 | 10993 | SDS | serine dehydratase | enzyme | 1.02 | 2.18 |
| 2 | 9021 | SOCS3 | suppressor of cytokine signaling 3 | phosphatase | 1.03 | 2.14 |
| 3 | 387763 | C11orf96 | chromosome 11 open reading frame 96 | other | 0.95 | 2.06 |
| 4 | 6289 | SAA2 | serum amyloid A2 | other | 1.05 | 1.95 |
| 5 | 1154 | CISH | cytokine inducible SH2 containing protein | other | 0.98 | 1.93 |
| 6 | 5596 | MAPK4 | mitogen-activated protein kinase 4 | kinase | 1.10 | 1.75 |
| 7 | 1723 | DHODH | dihydroorotate dehydrogenase (quinone) | enzyme | 0.97 | 1.73 |
| 8 | 5320 | PLA2G2A | phospholipase A2 group IIA | enzyme | 1.02 | 1.72 |
| 9 | 5105 | PCK1 | phosphoenolpyruvate carboxykinase 1 | kinase | 1.14 | 1.69 |
| 10 | 6288 | SAA1 | serum amyloid A1 | transporter | 1.02 | 1.64 |
| 11 | 3934 | LCN2 | lipocalin 2 | transporter | 1.03 | 1.64 |
| 12 | 9214 | FAIM3 | Fc fragment of IgM receptor | other | 1.02 | 1.61 |
| 13 | 644945 | KRT16P3 | keratin 16 pseudogene 3 | other | 1.08 | 1.55 |
| 14 | 5292 | PIM1 | Pim-1 proto-oncogene, serine/threonine kinase | kinase | 0.93 | 1.49 |
| 15 | 10344 | CCL26 | C-C motif chemokine ligand 26 | cytokine | 1.00 | 1.48 |
| 16 | 9510 | ADAMTS1 | ADAMTS type 1 motif 1 | peptidase | 0.98 | 1.48 |
| 17 | 4837 | NNMT | nicotinamide N-methyltransferase | enzyme | 1.04 | 1.47 |
| 18 | 11238 | CA5B | carbonic anhydrase 5B | enzyme | 1.02 | 1.47 |
| 19 | 14415 | GAD1 | glutamate decarboxylase 1 | enzyme | 1.11 | 1.45 |
| 20 | 220108 | FAM124A | family with sequence similarity 124 member A | other | 1.11 | 1.45 |
| 21 | 2243 | FGA | fibrinogen alpha chain | other | 1.08 | 1.45 |
| 22 | 7004 | TEAD4 | TEA domain transcription factor 4 | transcription | 1.11 | 1.43 |
| 23 | 3929 | LBP | lipopolysaccharide binding protein | transporter | 1.01 | 1.43 |
| 24 | 8740 | TNFSF14 | TNF superfamily member 14 | cytokine | 0.91 | 1.42 |
| 25 | 79689 | STEAP4 | STEAP4 metalloreductase | enzyme | 1.02 | 1.42 |
| 26 | 10406 | WFDC2 | WAP four-disulfide core domain 2 | other | 1.03 | 1.42 |
| 27 | 10912 | GADD45G | growth arrest and DNA damage inducible γ | other | 0.96 | 1.41 |
| 28 | 23151 | GRAMD4 | GRAM domain containing 4 | other | 0.97 | 1.41 |
| 29 | 1116 | CHI3L1 | chitinase 3 like 1 | enzyme | 0.99 | 1.41 |
| 30 | 7043 | TGFB3 | transforming growth factor beta 3 | growth factor | 1.00 | 1.41 |
| 31 | 27289 | RND1 | Rho family GTPase 1 | enzyme | 0.96 | 1.40 |
| 32 | 283777 | FAM169B | family with sequence similarity 169 member B | other | 1.00 | 1.39 |
| 33 | 6446 | SGK1 | serum/glucocorticoid regulated kinase 1 | kinase | 1.01 | 1.38 |
| 34 | 57509 | MTUS1 | microtubule associated scaffold protein 1 | other | 0.98 | 1.38 |
| 35 | 53905 | DUOX1 | dual oxidase 1 | enzyme | 1.01 | 1.38 |
| 36 | 7504 | NA | X-linked Kx blood group | transporter | 1.00 | 1.38 |
| 37 | 642273 | FAM110C | family with sequence similarity 110 member C | other | 1.08 | 1.37 |
| 38 | 10507 | SEMA4D | semaphorin 4D | receptor | 1.12 | 1.37 |
| 39 | 8829 | NRP1 | neuropilin 1 | receptor | 1.09 | 1.37 |
| 40 | 3726 | JUNB | JunB proto-oncogene, AP-1 transcription factor subunit | transcription | 1.11 | 1.36 |
| 41 | 3283 | HSD3B1 | hydroxy-δ-5-steroid dehydrogenase, 3β- and steroid δ-isomerase 1 | enzyme | 0.99 | 1.36 |
| 42 | 6590 | SLPI | secretory leukocyte peptidase inhibitor | other | 1.07 | 1.36 |
| 43 | 3394 | IRF8 | interferon regulatory factor 8 | transcription | 1.08 | 1.36 |
| 44 | 10957 | PNRC1 | proline rich nuclear receptor coactivator 1 | other | 1.06 | 1.36 |
| 45 | 388125 | C2CD4B | C2 calcium dependent domain containing 4B | other | 0.98 | 1.36 |
| 46 | 89870 | TRIM15 | tripartite motif containing 15 | other | 0.97 | 1.35 |
| 47 | 6347 | CCL2 | C-C motif chemokine ligand 2 | cytokine | 1.09 | 1.35 |
| 48 | 10509 | SEMA4B | semaphorin 4B | other | 1.03 | 1.34 |
| 49 | 64856 | VWA1 | von Willebrand factor A domain containing 1 | other | 0.99 | 1.34 |
| 50 | 116372 | LYPD1 | LY6/PLAUR domain containing 1 | GPCR | 0.97 | 1.34 |
The gene ID, symbol, Entrez gene name, type of gene, and average expression level are indicated in the table. Expression levels of genes in IFNα- and CDM-3008-treated cells were divided by the expression levels of genes in DMSO-treated cells. Genes that were specifically upregulated in CDM-3008-treated cells and not in IFNα-treated cells were selected, and the top 50 most highly expressed genes are shown.