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. 2019 Jun 12;14(6):e0218126. doi: 10.1371/journal.pone.0218126

Fig 4. PDH activity promotes tumor growth in both obesity-associated and obesity-independent tumor cell lines.

Fig 4

(A) Cell division in tumor cell lines incubated with or without insulin, with or without a PDH inhibitor. (B) Cell division in tumor cell lines incubated with or without the PDH activator dichloroacetate. In both panels, n = 6 replicates per condition, normalized to controls from the same cell line. *P<0.05, **P<0.01, ***P<0.001, ****P<0.0001 by ANOVA with Bonferroni’s multiple comparisons test (panel (A)) or by the 2-tailed unpaired Student’s t-test (panel (B)). Data are the mean± S.E.M.