Table 2. Primary univariate and cox regression multivariate analysis of clinicopathologic variables in relation to overall survival in the combined stage I-III cohort.

Clinicopathologic variables	No., (%), (n = 3067)	Univariate analysis, HR (95% CI)	P	Multivariate analysis, HR (95% CI)	P
Gender
M	1536 (50.1%)	1 (referent)	0.016	1 (referent)	0.001
F	1531 (49.9%)	0.839 (0.727–0.968)_		0.837 (0.727–0.968)
Age
≤70	1311 (42.7%)	1 (referent)	<0.001	1 (referent)	<0.001
>70	1756 (57.3%)	1.864 (1.599–2.173)		2.289 (1.984–2.640)
T stage
1	219 (7.1%)	1 (referent)	<0.001	1 (referent)	<0.001
2	529 (17.2%)	0.923 (0.574–1.485)		0.954 (0.648–1.405)
3	1617 (52.7%)	2.319 (1.535–3.502)		1.575 (1.114–2.228)
4	702 (22.9%)	5.287 (3.485–8.020)		2.870 (2.003–4.112)
N stage
0	1717 (56.0%)	1 (referent)	<0.001	1 (referent)	<0.001
1	885 (28.8%)	1.665 (1.405–1.974)		1.369 (1.172–1.598)
2	465 (15.2%)	3.649 (3.058–4.356)		2.669 (2.234_3.189)
Site
Right-sided	1403 (45.7%)	1 (referent)	0.291
Left-sided	1664 (54.3%)	0.984 (0.802–1.069)