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. 2019 May 2;55(1):131–141. doi: 10.3892/ijo.2019.4792

Figure 1.

Figure 1

BK is overexpressed in the serum of patients with CC. (A) The expression level of serum BK was examined in CC (n=130), CIN (n=35) and control (n=35) patients by ELISA. The average expression level of BK was significantly higher in patients with CC compared with patients with CIN (P<0.05) and control patients (P<0.01). (B) Expression level of serum BK in CC (n=65) and CIN (n=35) patients pre- and post-surgery. The pre-operative BK level was prominently higher than the corresponding post-operative BK level in patients with CC (P<0.0001). For patients with CIN, there was no significant difference in the BK levels before and after surgery. (C) ROC curves were depicted and the AUCs of these biomarkers were calculated. The AUC of BK alone was 0.671 (95% CI: 0.590-0.751) and SCCA was 0.657 (95% CI: 0.579-0.735). Combined both, the AUC was 0.752 (95% CI: 0.682-0.821). *P<0.05, **P<0.01 and ***P<0.001, n.s. non-statistical significance. BK, bradykinin; CC, cervical cancer; CIN, cervical intraepithelial neoplasia; SCCA, squamous cell carcinoma-related antigen.