Table 1.
Patient demographics and baseline characteristics
| GHD (n = 790) | TS (n = 66) | |
|---|---|---|
| Sex,n (%) | ||
| Female | 266 (33.7) | 66(100) |
| Male | 524 (66.3) | - |
| Age, years | ||
| Mean (SD) | 9.30 (3.44) | 8.06 (3.74) |
| Median (range) | 9.70 (0.21 to 17.78) | 7.86 (2.05 to 15.82) |
| Age groups | ||
| ≤5 years,n (%) | 110 (13.9) | 15 (22.7) |
| >5 to 10 years,n (%) | 308 (39.0) | 28 (42.4) |
| >10 years,n (%) | 372 (47.1) | 23 (34.8) |
| Bone age, years | ||
| Mean (SD) | 7.55 (3.41) | 7.64 (3.17) |
| Median (range) | 8.00 (0.09 to 17.00) | 8.27 (2.06 to 13.25) |
| Pre-pubertal | ||
| Female, % | 79.1 | 93.9 |
| Male, % | 86.1 | – |
| Dose, µg/kg/day | ||
| Start of study [mean (SD)] | 28.63 (5.95) | 41.62 (9.78) |
| After 12 months [mean (SD)] | 31.20 (5.89) | 43.48 (7.72) |
| Documented duration of treatment, months | ||
| Mean (SD) | 45.4 (29.7) | 44.2 (29.3) |
| Median (range) | 38.00(9 to 215) | 40.0(9 to 152) |
| Height SDS | ||
| Mean (SD) | –2.46 (0.81) | –2.68 (0.98) |
| Median (range) | –2.42 (–9.15 to 0.79) | –2.64 (–5.58 to 0.07) |
| Administration device,n (%) | ||
| NI | 192 (24.3) | 11 (16.7) |
| NF | 419 (53.0) | 36 (54.5) |
| Unknown | 148 (18.7) | 16 (24.2) |
| Switch | 31 (3.9) | 3 (4.5) |
GHD, growth hormone deficiency; NF, needle-free; NI, needle injection; SD, standard deviation; SDS, SD score; TS, Turner syndrome.