Table 2.
Near adult height (NAH) of female and male patients with growth hormone deficiency (GHD) using needle injection (NI) or needle-free (NF) administration devices
| Device | n | Mean | SD | Min | Max | Percentiles |
|||
|---|---|---|---|---|---|---|---|---|---|
| 25th | 50th (median) | 75th | |||||||
| Female | |||||||||
| NI | |||||||||
| NAH, cm | 24 | 155.3 | 6.2 | 145.7 | 177.6 | 152.6 | 154.3 | 158.4 | |
| NAH, % of Tanner | 24 | 96.3 | 4.9 | 82.5 | 108.8 | 93.9 | 96.5 | 98.6 | |
| Height gain, cm | 24 | 25.2 | 9.3 | 3.2 | 47.4 | 18.9 | 23.9 | 32.5 | |
| NAH SDS | 24 | –1.4 | 0.9 | –2.6 | 1.7 | –1.9 | –1.6 | –0.9 | |
| Height SDS gain | 24 | 1.0 | 0.4 | –0.2 | 1.7 | 0.7 | 1.1 | 1.3 | |
| NF | |||||||||
| NAH, cm | 30 | 155.4 | 5.5 | 142.5 | 166.0 | 152.1 | 155.5 | 159.0 | |
| NAH (% of Tanner) | 19 | 96.8 | 3.3 | 87.5 | 100.2 | 95.0 | 97.8 | 99.6 | |
| Height gain, cm | 30 | 31.8 | 18.6 | 8.4 | 87.2 | 17.2 | 27.9 | 36.5 | |
| NAH SDS | 30 | –1.4 | 0.6 | –3.2 | –0.1 | –1.8 | –1.4 | –1.0 | |
| Height SDS gain | 30 | 1.2 | 0.9 | –0.1 | 4.2 | 0.8 | 1.2 | 1.5 | |
| Total | |||||||||
| NAH, cm | 54 | 155.4 | 5.8 | 142.5 | 177.6 | 152.4 | 155.0 | 158.6 | |
| NAH (% of Tanner) | 43 | 96.5 | 4.2 | 82.5 | 108.8 | 94.6 | 96.9 | 99.1 | |
| Height gain, cm | 54 | 28.8 | 15.4 | 3.2 | 87.2 | 18.3 | 25.1 | 33.6 | |
| NAH SDS | 54 | –1.4 | 0.7 | –3.2 | 1.7 | –1.9 | –1.4 | –1.0 | |
| Height SDS gain | 54 | 1.1 | 0.7 | –0.2 | 4.2 | 0.7 | 1.1 | 1.5 | |
| Male | |||||||||
| NI | |||||||||
| NAH, cm | 14 | 165.4 | 4.9 | 158.7 | 173.4 | 161.1 | 164.0 | 170.2 | |
| NAH, % of Tanner | 14 | 95.1 | 4.2 | 87.8 | 102.3 | 91.6 | 95.5 | 99.0 | |
| Height gain, cm | 14 | 34.5 | 17.5 | 11.3 | 71.3 | 22.4 | 31.2 | 42.8 | |
| NAH SDS | 14 | –1.5 | 0.8 | –2.6 | –0.2 | –2.3 | –1.4 | –1.0 | |
| Height SDS gain | 14 | 0.8 | 0.7 | –0.4 | 1.9 | 0.2 | 0.8 | 1.3 | |
| NF | |||||||||
| NAH, cm | 27 | 166.8 | 6.3 | 153.9 | 180.5 | 162.7 | 167.5 | 171.0 | |
| NAH, % of Tanner | 22 | 95.4 | 2.9 | 86.3 | 99.8 | 93.9 | 96.4 | 97.0 | |
| Height gain, cm | 27 | 38.7 | 19.5 | 15.9 | 76.1 | 21.0 | 35.0 | 50.9 | |
| NAH SDS | 27 | –1.3 | 0.7 | –2.6 | 0.2 | –1.9 | –1.3 | –0.7 | |
| Height SDS gain | 27 | 0.8 | 0.8 | –0.8 | 2.4 | 0.1 | 0.7 | 1.2 | |
| Total | |||||||||
| NAH, cm | 41 | 166.3 | 5.8 | 153.9 | 180.5 | 162.1 | 167.3 | 170.3 | |
| NAH, % of Tanner | 36 | 95.3 | 3.4 | 86.3 | 102.3 | 92.6 | 95.9 | 97.1 | |
| Height gain, cm | 41 | 37.2 | 18.7 | 11.3 | 76.1 | 21.9 | 33.9 | 47.7 | |
| NAH SDS | 41 | –1.4 | 0.7 | –2.6 | 0.2 | –2.0 | –1.3 | –0.8 | |
| Height SDS gain | 41 | 0.8 | 0.7 | –0.8 | 2.4 | 0.2 | 0.8 | 1.2 | |
NAH defined as chronological age ≥12 years for girls and ≥14 years for boys and at least one of the following: height velocity (HV) <2 cm/year or bone age ≥14 years for girls and ≥16 years for boys. SD, standard deviation; SDS, SD score.