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. 2019 Jun 12;39(24):4657–4667. doi: 10.1523/JNEUROSCI.2233-18.2019

Figure 1.

Figure 1.

Knockdown of Npas2 in the NAc leads to an increase in excitatory transmission onto MSNs. A, Bilateral targeting of AAV2-Scramble-shRNA or AAV2-Npas2-shRNA to the NAc (left) and localization of GFP-tagged shRNA (inset). B, Representative traces of mEPSCs sampled from scramble and Npas2-shRNA infected MSNs. C, Summary of mEPSC amplitude in cells from both groups (white, Scramble; gray, Npas2-shRNA). D, Summary of mEPSC frequency. E, Representative traces of AMPAR and NMDAR EPSCs from scramble and Npas2-knockdown MSNs (left). AMPA/NMDA ratio of evoked responses from both groups. n = cells/animals. *p < 0.05. AC, Anterior commissure; AcbC, accumbal core; AcbSh, accumbal shell; CPu, caudate putamen.