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. 2019 Jun 12;39(24):4657–4667. doi: 10.1523/JNEUROSCI.2233-18.2019

Figure 2.

Figure 2.

Increased excitatory synaptic transmission following Npas2-knockdown is specific to D1R-containing MSNs. A, Drd1a-tdTomato reporter mice were used to visualize D1R-MSNs and non-D1R MSNs in NAc slices from mice receiving either AAV2-Scramble-shRNA or AAV2-Npas2-shRNA. B, Summary of mEPSC amplitude in D1R and non-D1R neurons infected with Scramble or Npas2-shRNA virus. C, Cumulative probability of event amplitudes. D, Frequency of miniature events in both groups and cell types. E, Cumulative probability of mEPSC inter-event intervals. F, Summary of AMPAR–NMDAR ratio of evoked currents. Representative traces of AMPAR (−70 mV) and NMDAR (40 mV) EPSCs from scramble or Npas2-shRNA viral infected D1R neurons. n = cells/animals. *p < 0.05, **p < 0.01, ***p < 0.001. AC, Anterior commissure; AcbC, accumbal core; AcbSh, accumbal shell; CPu, caudate putamen.