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Knockdown of Npas2 attenuates cocaine-induced potentiation of D1R-MSN excitatory transmission. Representative traces of AMPAR-mediated mEPSCs (−70 mV) from D1R- and non-D1R MSNs infected with scramble or Npas2-shRNA from mice receiving (A) saline or (B) 20 mg/kg cocaine (i.p.) for 7 d. C, Summary of mEPSC amplitude. D, Summary of mEPSC frequency. n = cells/animals. *p < 0.05, **p < 0.01.
