Figure 6.

Viral-mediated knockdown of Npas2 specifically in D1R-MSNs reduces cocaine CPP. A, Timeline of stereotaxic viral injections, conditioning paradigm and histological verification. B, Representative micrograph of mCherry expression indicating presence and location of Cre-inducible shRNA virus within the NAc (left) and 20× image of virus expression within NAc cells (right). C, CPP score (test–pretest duration) for scramble and Npas2-shRNA-treated Drd1a-Cre and Drd2-Cre mice. AC, Anterior commissure; AcbC, accumbal core; AcbSh, accumbal shell. n = animals. *p < 0.05.