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. 2019 Jun 12;39(24):4797–4813. doi: 10.1523/JNEUROSCI.0839-18.2019

Figure 1.

Figure 1.

Loss of FMRP alters the central processing of auditory signals. A, Plots of the ABR thresholds for wild-type mice (N = 17 animals) and Fmr1−/y mice (N = 28 animals). B, ABR wave recordings from WT and Fmr1−/y mice stimulated at 11.3 kHz at different sound levels (35–90 dB). Arrows indicate wave IV of the ABR response. C, D, Plots of the amplitudes (C) and latencies (D) of ABR waves I and IV as a function of sound levels (40–90 dB). The magnitude of wave I is decreased for high sound levels (p = 0.0002) only, and there is a significant increase in wave IV amplitude in Fmr1−/y mice at most sound levels tested (p < 0.0001) without significant change in the ABR latencies. Error bars indicate the mean ± SEM. In C, asterisks indicate statistical significance (two-way ANOVA followed by Bonferroni–Dunn post-test).