Figure 7.

AUT2 fails to alter high- and low-threshold K⁺ currents in the presence of the Kv3 channel blocker TEA. A–D, Voltage-clamp recordings of the high-threshold (A, C) and low-threshold (B, D) potassium currents in wild-type and in Fmr1^−/y mice. Panels on the right show the current–voltage and the conductance–voltage (normalized to maximal value at +60 mV; G/G₊₆₀) curves for high- and low-threshold K⁺ currents before and after AUT2, in the presence of the Kv3 channels blocker TEA (1 mm). AUT2 failed to alter the magnitude and the conductance of both high- and low-threshold potassium currents in these conditions.