Figure 9.

AUT2 rescues the auditory function of Fmr1^−/y mice. A, Representative ABR traces recorded from Fmr1^−/y mice before and 20 min after intraperitoneal injection of AUT2 (30 mg/kg). Arrows indicate wave IV of the ABR response. B, Plots of the amplitudes and latencies of ABR waves I and IV as a function of sound level before and after injection of AUT2. The group data show a significant decrease in the amplitude of ABR wave IV after AUT2 injection (p = 0.001) with no change in the amplitude of wave I (p = 0.3). In B, asterisks indicate statistical significance (two-way ANOVA followed by Holm–Sidak post-test).