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Kinase and Phosphatase Classification Based on Abundance-Dependent Effects on Cancer Signaling Network
(A) t-SNE analysis of overexpressed kinases and phosphatases performed on signed-BP-R2 of all measured phosphorylation sites with and without EGF stimulation, color coded by hierarchical clusters.
(B) The mean signed-BP-R2 values of all measured phosphorylation sites in each cluster of kinases or phosphatases shown in literature-guided canonical signaling network visualizations.
