Figure 3.
Functional Enrichment Analysis of Kinases and/or Phosphatases in Each Cluster
(A) An unrooted tree shows the hierarchical clustering of the kinases and phosphatases based on their signed-BP-R2 scores. Terms of enriched functions (p < 0.05) from each cluster are annotated, with circle color indicating the p value and circle size showing the coverage of cluster components. The percentage of associated proteins is indicated by the size of the adjacent circle.
(B) Functional association analysis performed with the STRING database (Szklarczyk et al., 2017) for cluster 7. Confident edges are shown in the network. Functional enrichments are shown as color-coded pies, with the pie radius indicating the p value.