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. 2019 Jun 12;5(6):eaaw4991. doi: 10.1126/sciadv.aaw4991

Fig. 6. Direct cocultures of osteoclasts with AdOPG-infected hMSCs on Col-GAG and MC-GAG increase p-Smad1/5, Runx2, p-ERK1/2, and mineralization.

Fig. 6

(A) Representative μCT images and (B) quantitative analysis of direct cocultures of osteoclasts with empty scaffold (empty + OC), control hMSCs (hMSC + OC), or AdOPG-transduced hMSCs (hMSC/AdOPG + OC) on Col-GAG or MC-GAG for 14 days. Significant post hoc comparisons following ANOVA indicated with P values. (C) Western blot of control of AdOPG-transduced primary hMSCs differentiated on Col-GAG or MC-GAG materials cocultured with osteoclasts for 14 days.