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Calculated ECF/Blood Partition Coefficients (Kpu,u)
| Dose (mg/kg) | AUC0−∞ blood (μg/mL × min × 104) | AUC0−∞ ECF (μg/mL × min × 104) | Kpu,u |
|---|---|---|---|
| 200 | 2.05 | 0.160 | 0.078 |
| 400 | 5.80 | 0.501 | 0.086 |
| 600 | 10.4 | 1.01 | 0.097 |
| 800 | 15.0 | 1.62 | 0.107 |
| 1000 | 19.6 | 2.33 | 0.119 |
| 1500 | 30.0 | 4.53 | 0.151 |
