Table IV.

Parameters and Conditions with Exhibited Sensitivity with Respect to One or More Endpoints

Parameter	Dose	±SE	AUC0−∞	CLR	EMAX
			% change
KP,LI	200	−3	28.7	7.68	19.6
KP,LI	600	−3	15.8	38.3	21.0
KP,LI	1500	−3	−2.98	34.6	6.77
KM,R	200	−3	4.55	−56.5	0.876
KM,R	600	−3	11.3	−41.0	1.57
KM,R	200	3	−3.58	50.0	−0.705
KM,R	600	3	−6.88	32.3	−0.767
VMAX,R	200	−3	−5.26	71.0	−1.36
VMAX,R	600	−3	−16.9	81.2	−3.05
VMAX,R	1500	−3	−20.6	50.0	−2.59
VMAX,R	600	−1	−5.01	20.9	−0.98
VMAX,R	200	3	2.40	−29.5	0.539
VMAX,R	600	3	11.4	−37.4	2.66
VMAX,R	1500	3	23.8	−32.1	1.97
KM,EF	200	−3	0.006	0.470	−45.5
KM,EF	600	−3	0.213	0.605	−36.7
KM,EF	200	3	−0.006	0.466	28.1
VMAX,EF	200	−3	−0.005	0.467	26.2
VMAX,EF	600	−3	−0.135	0.653	29.0
VMAX,EF	200	3	0.002	0.469	−20.9
KM,UP	200	−3	−0.011	0.464	59.9
KM,UP	600	−3	0.003	0.626	43.0
KM,UP	200	3	0.003	0.469	−28.7
KM,UP	600	3	0.023	0.650	−22.7
VMAX,UP	200	−3	0.004	0.469	−33.0
VMAX,UP	600	−3	0.024	0.652	−31.6
VMAX,UP	1500	−3	1.04	−0.155	−27.9
VMAX,UP	200	3	−0.004	0.466	31.1
VMAX,UP	600	3	0.013	0.634	27.1
KM,MET	200	−3	−21.0	−0.794	−0.971
KM,MET	200	3	48.7	−2.36	0.888
KM,MET	600	3	23.0	−5.93	0.681

Values are in bold to highlight the instances of sensitivity that the endpoint changed greater than or equal to 20%