Table 1.

DUBs that Regulate the DDR Pathways.

DUB	Substrate/Target	Process	Functional Consequence	References
USP7	XPC	NER	May regulate the stabilization and chromatin loading of XPC for GG-NER	[60, 61, 64]
	UVSSA & ERCC6/CSB	NER	Regulates the stability of ERCC6/CSB for TC-NER	[61, 66–69]
	ALKBH2 & ALKBH3	BER	Promotes alkylation damage resistance & regulates sensitivity to alkylating agents	[58]
	RNF168 & RNF169	DSB	Stabilizes RNF168 and may regulate BRCA1 recruitment at DSB sites; HR repair increased via USP7-RNF169 axis	[98, 100]
	PCNA	TLS	Stabilizes RAD18 and Pol η	[42–44]
USP7S	Mule/ARF-BP1	BER	Stabilizes DNA Polymerase β and λ	[59]
USP24	DDB2	NER	Allow proper detection of UV-induced damage by stabilizing E3 ligase	[60, 61, 63]
USP45	ERCC1	NER	Promotes translocation of ERCC1 to foci of DNA damage and ability of cells to repair CPDs	[70, 71]
USP11	XPC	NER	Proper damage recognition of lesions	[65]
	H2AX	DSB	HR repair increased	[85, 86]
USP9x	ALKBH2 & ALKBH3	BER	Promotes alkylation damage resistance & regulates sensitivity to alkylated agents	[58]
	MCL-1	DSB	Stabilizes MCL-1 & HR repair increased; NHEJ repair decreased	[101, 102]
USP47	Polymerase β	BER	Synthesize nicked DNA	[55]
OTUD4	USP7 & USP9x, ALKBH2 & ALKBH3	BER	Promotes alkylation damage resistance via stabilization of AlkB homologues	[58]
OTUB1	UBC13	DSB	HR repair decreased	[95–97]
OTUB2	L3MBTL1 & K63-linked ubiquitin chains	DSB	HR repair increased; NHEJ repair decreased	[72, 83]
USP34	RNF168	DSB	HR repair decreased	[99]
BAP1	H2A	DSB	HR repair increased	[104–106]
UCHL5	NFRKB	DSB	HR repair increased	[87–91]
USP4	CtlP & MRN	DSB	HR repair increased	[92–94]
BRCC36	K63	DSB	HR repair increased; NHEJ repair decreased	[72, 80, 84]
POH1	K63	DSB	HR repair decreased	[21, 78, 80–82]
USP1	FANCD2/FANCI	FA	Efficient foci formation at sites of DNA Damage	[40, 45–53]
	PCNA	TLS	Promotes recruitment of TLS polymerases	[41]
	???	DSB	HR repair increased; NHEJ decreased	[103]