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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Respir Physiol Neurobiol. 2019 May 3;266:54–65. doi: 10.1016/j.resp.2019.04.014

Fig. 6. Long-lasting effects of sustained SubP applications in pontine brainstem-spinal cords.

Fig. 6.

(A) The time course of burst frequency effects are shown for a sustained SubP application (one 9-min application) at 100 nM (black circles). Data from time control experiments are shown (white squares). Frequency plasticity was observed following sustained SubP applications, but a much lower amount compared to intermittent 100 nM SubP applications. (B) Mean percent change in burst frequency at the 90-min time point is shown for males (white circles) and females (white squares) following 0 nM SubP (time controls) and 100 nM SubP sustained applications. Individual data points in each group are shown as black circles. When comparing data only at the 90-min time point, frequency plasticity was expressed and there was a significant drug-dependent effect. There were no sex-dependent differences in frequency plasticity. (C) There were no long-lasting decreases in burst amplitude with sustained SubP applications compared to time controls. Statistics symbols as in Fig. 2 legend.