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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Mol Microbiol. 2019 Apr 2;111(6):1671–1688. doi: 10.1111/mmi.14245

Figure 1. Metabolic map of prdR regulated genes.

Figure 1

Conversion of glucose to pyruvate (glycolysis) and oxidation of amino acids to carboxylic acids (Stickland metabolism) generate NADH. Proline reductase (1), glycine reductase (2) and the succinate-acetyl CoA pathway to butyrate (3, 4) generate NAD+. Solid lines indicate single enzyme steps, whereas dotted lines indicate multienzyme steps in the pathways. Specific pathways and genes that encode the relevant enzymes are denoted as follows: (1) D-proline reductase (CD3236–3244, prd); (2) glycine reductase (CD2348-CD2358, grd); (3) succinate reduction (CD2344–CD2338); (4) conversion of acetyl CoA to butyryl CoA (CD1054–CD1059); (5) ethanolamine utilization (CD1906-CD1925, eut); and (6) alcohol dehydrogenase (CD2966, adhE). In the prdR mutant, the prd genes were underexpressed, but the other indicated pathways were all overexpressed at least 5-fold compared to the wild-type.

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