Table 1.
Rates of PD-L1 expression in UCV using cutoff values to define positivity as 1% of TC (Table 1a) or 5% (Table 1b)
| Table 1a | SP263 | SP142 | 22C3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Histologic differentiation (n) | Tumors pos.* (n, %) | TC (%; mean) | TC (H-score, mean) | IC (%; mean | Tumors pos.* (n, %) | TC (%; mean) | TC (H-score, mean) | IC (%; mean | Tumors pos.* (n, %) | TC (%; mean) | TC (H-score, mean) | IC (%; mean |
| Micropapillary (19) | 13 (69%) | 5 | 7 | 12 | 6 (32%) | 2 | 4 | 5 | 7 (37%) | 2 | 4 | 8 |
| Squamous differentiation (16) | 14 (88%) | 42 | 86 | 12 | 14 (88%) | 20 | 43 | 9 | 15 (94%) | 30 | 50 | 14 |
| Nested (14) | 5 (36%) | 4 | 7 | 10 | 1 (7%) | 3 | 8 | 4 | 4 (29%) | 4 | 7 | 8 |
| Plasmacytoid (14) | 5 (36%) | 5 | 8 | 9 | 3 (21%) | 1 | 1 | 3 | 2 (14%) | 8 | 3 | 4 |
| Small cell carcinoma (12) | 2 (17%) | 9 | 24 | 7 | 2 (17%) | 7 | 19 | 3 | 2 (17%) | 3 | 18 | 6 |
| Glandular differentiation (9) | 6 (67%) | 6 | 9 | 14 | 5 (56%) | 2 | 2 | 5 | 6 (67%) | 9 | 4 | 10 |
| Total (84) | 45 (54%) | 13 | 25 | 11 | 31 (37%) | 6 | 13 | 5 | 36 (43%) | 9 | 15 | 8 |
| Table 1b | SP263 | SP142 | 22C3 | |||||||||
| Histologic differentiation (n) | Tumors pos.* (n, %) | TC (%; mean) | TC (H-score, mean) | IC (%; mean | Tumors pos.* (n, %) | TC (%; mean) | TC (H-score, mean) | IC (%; mean | Tumors pos.* (n, %) | TC (%; mean) | TC (H-score, mean) | IC (%; mean |
| Micropapillary (19) | 6 (32%) | 5 | 7 | 12 | 2 (11%) | 2 | 4 | 5 | 3 (16%) | 2 | 4 | 8 |
| Squamous differentiation (16) | 14 (88%) | 42 | 86 | 12 | 13 (81%) | 20 | 43 | 9 | 15 (94%) | 30 | 50 | 14 |
| Nested (14) | 1 (7%) | 4 | 7 | 10 | 1 (7%) | 3 | 8 | 4 | 1 (7%) | 4 | 7 | 8 |
| Plasmacytoid (14) | 3 (21%) | 5 | 8 | 9 | 0 (0%) | 1 | 1 | 3 | 2 (14%) | 8 | 3 | 4 |
| Small cell carcinoma (12) | 2 (17%) | 9 | 24 | 7 | 2 (17%) | 7 | 19 | 3 | 2 (17%) | 3 | 18 | 6 |
| Glandular differentiation (9) | 5 (56%) | 6 | 9 | 14 | 1 (11%) | 2 | 2 | 5 | 2 (22%) | 9 | 4 | 10 |
| Total (84) | 31 (37%) | 13 | 25 | 11 | 19 (23%) | 6 | 13 | 5 | 25 (30%) | 9 | 15 | 8 |
TC: Tumor cells, IC: immune cells