Table 6.
Performance of KBP on H&N IMRT/VMAT (studies with 10 or more test cases)
| Articles | Method type | Sample size | Validation target | Validation metrics | OARs | Target |
|---|---|---|---|---|---|---|
| Wu et al.44 | Case/DVH | 15 | Re‐planned vs clinical | Mean difference |
Cord + 4 D0.1 cc ‐6.9 Bstem D0.1 cc ‐7.7 Cparotid V30 ‐8.7 |
|
| Wu et al.45 | Case/DVH | 40 | Re‐planned vs clinical | Mean difference |
Cord + 4 D0.1 cc ‐1.68 Bstem D0.1 cc ‐2.77 Esoph D1 cc 1.52 I‐inn ear Dmean ‐3.65 C‐inn ear Dmean ‐4.83 |
PTV70 V95 0.31 PTV63 V95 0.4 PTV70 D5‐95 ‐0.9 Ring63 D5‐95 ‐0.87 Ring58.1 D5‐95 ‐1.61 |
| Yuan et al.9 | Model/DVH | 24 | Predicted vs clinical | Error bound of parotid mean dose | 63% cases are within 6% error bound | |
| Lian et al.10 – fixed gantry predicting tomo IMRT | Model/DVH | 44 Tomo/53 FG | Predicted vs clinical | Error bound | FG predict Tomo parotid mean dose: 92% cases within 10% error bound | |
| Wu et al.47 – IMRT predict VMAT | Case/DVH | 12 | Re‐planned VMAT vs clinical IMRT | Mean difference |
Cord + 4 D.1 cc ‐3.7 Bstem D.1 cc ‐4.9 Larynx V50 ‐5.3 Brach plexus D.1 cc ‐1.6 Inner ear Dmean ‐4.4 |
|
| Tol et al.12 | RapidPlan | 15 | Re‐planned vs clinical | Mean difference |
Dmeans: Oral Cavity ‐2.7 Cparotid ‐1.2 Lower Larynx ‐5 Upper Larynx ‐5.7 Inferior PCM ‐5.8 Superior PCM –4.4 UES ‐3.5 Comp_swal ‐4.4 |
PTVb V95 0.5 |
| Yuan et al.13 | Model/DVH | 20 | Predicted vs clinical |
Median difference of parotid D50 Sum of residuals of parotid DVH |
Bilateral sparing cases: 0.34 Single‐side sparing cases: 2.2 Bilateral sparing cases: ‐0.002 Single‐side sparing cases: ‐0.08 |
|
| Schmidt et al.61 | Case/voxel | 10 | Re‐planned vs clinical | Mean difference |
Larynx Dmedian ‐3.6 Oral cavity Dmedian ‐5.5 |
Primary Dmax 1.3 Boost Dmax ‐1.3 HI ‐2.4 S_index ‐0.5 |
| Tol et al.18 | RapidPlan | 20 | Re‐planned vs clinical | Mean difference |
Dmean:# Comp_sali ‐2.0 Oral cavity ‐3.6 Comp_swal ‐5.9 |
|
| Zhang et al.42 | Model/DVH | 148 | Predicted vs clinical | Weighted root mean square error of DVH | ~5.5% |
KBP, knowledge‐based planning; IMRT, intensity‐modulated radiation therapy; VMAT, volumetric arc therapy.
The difference direction is “KBP – Clinical”. Thus, negative values mean KBP value is smaller. Where differences are reported, only those that are statistically significant with a P‐value < 0.05 are listed in this table. The sign # indicates the significance is unclear and the sign ~ indicates the value is estimated from a graph.