Table 7.
Performance of KBP on lung IMRT/VMAT (studies with 10 or more test cases)
| Articles | Method type | Sample size | Validation target | Validation metrics | OARs | Target |
|---|---|---|---|---|---|---|
| Snyder et al. | RapidPlan | 25 | Re‐planned vs clinical | Mean difference |
IMRT: Spinal Cord: D1.2 cc ‐0.5 D0.35 cc ‐0.8 D0.035 cc ‐1.0 VMAT: Esphagus: D0.035 1.1 |
IMRT: GI 0.66 VMAT: GI 0.25 |
| McIntosh et al. | Case/voxel | 17 | Predicted vs clinical | Mean average difference over DVH of all ROIs | 1.33a | |
| Faught et al. | RapidPlan | 20 (functional‐guided plans) | Re‐planned vs clinical | Mean difference |
Functional lung: V20 ‐1.8 Dmean ‐0.95 Lung‐GTV: V20 ‐1.6 Dmean ‐0.66 Esophagus: Dmean –2.6 |
KBP, knowledge‐based planning; IMRT, intensity‐modulated radiation therapy; VMAT, volumetric arc therapy.
The difference direction is “KBP – Clinical”. Thus, negative values mean KBP value is smaller. Where differences are reported, only those that are statistically significant with a P‐value < 0.05 are listed in this table.
a
Note that mean average difference (MAD) is not significant.